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Document 0090
DOCN M9480090
TI Comparison of a lesion-inducing isolate and a non-lesional isolate of
Candida albicans in an immunosuppressed rat model of oral candidiasis.
DT 9410
AU Allen CM; Saffer A; Meister RK; Beck FM; Bradway S; Section of Oral and
Maxillofacial Surgery and Pathology, Ohio; State University, Columbus
43210.
SO J Oral Pathol Med. 1994 Mar;23(3):133-9. Unique Identifier : AIDSLINE
MED/94293200
AB Two distinct strain-related patterns of organism-host interaction on
dorsal tongue of immunocompetent rats have been identified for Candida
albicans: some isolates induce mucosal lesions, while other isolates
penetrate the keratin layer but do not produce a lesion. This study
examined the behavior of each of the two types of isolates in a
cyclosporin-immunosuppressed rat model. Groups B (normal) and D
(cyclosporin) were orally inoculated with a lesion-inducing isolate of
C. albicans, while a non-lesional isolate was given to Groups A (normal)
and C (cyclosporin). A typical dorsal tongue lesion developed in 4/18
rats in Group B and in 13/16 in Group D (P = 0.00267). No significant
difference in infection rate between the normal and cyclosporin-treated
animals was seen for the non-lesional isolate. The lack of a host
inflammatory response associated with the non-lesional isolate may
represent an ecologic advantage for the organism.
DE Animal Candida albicans/*CLASSIFICATION/ISOLATION & PURIF/*PHYSIOLOGY
Candidiasis, Oral/*MICROBIOLOGY/PATHOLOGY Comparative Study
Cyclosporine CD4-CD8 Ratio Ecology Female Graft Rejection/PATHOLOGY
*Immunocompromised Host Keratin Mouth Mucosa/MICROBIOLOGY/PATHOLOGY
Rats Rats, Inbred ACI Rats, Sprague-Dawley Skin
Transplantation/IMMUNOLOGY/PATHOLOGY Support, Non-U.S. Gov't
T-Lymphocytes, Helper-Inducer/PATHOLOGY T-Lymphocytes,
Suppressor-Effector/PATHOLOGY Tongue/*MICROBIOLOGY/PATHOLOGY JOURNAL
ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).